0652 Subjective and objective sleep disturbances in individuals with psychotic disorders and their first-degree relatives

Abstract Introduction Sleep disturbances commonly precede or precipitate psychotic disorders. The primary goals of the present study are to compare self-reports sleep quality and chronotype with objective measurements investigate their relations clinical symptoms psychotic-like experiences (PLEs) in early course, minimally treated patients disorders (PSY), young, first-degree relatives (familial high risk: FHR) matched controls. Methods Seventy-three participants (13-35 yrs, n(PSY)=19, n(Controls)=30, n(FHR)=24) completed self-report measures (PSQI), (MEQ) PLEs (Chapman Scales). were objectively measured actigraphy (average duration measurements: 12 days). Psychosis FHR groups rated on Positive Negative Syndrome Scale (PANSS) by an expert clinician. Results PSQI was significantly different between (F(2,67)= 11.8, p< .001), this reflected that compared controls, both psychosis (p<.001) (p=002) had worse self-reported quality. For quality, we observed a main effect day-to-day variability total time (F(2,46)= 3.24, p=.048) , higher PSY than controls (p= .038). Symptom severity correlated (r=.31, p=.047), reflecting those more disturbances. entire sample also (r=.41, p<.001). We did not observe any correlations symptoms. There no group differences (subjective objective). Chronotype correlate PLEs. Conclusion While early-course report significant disturbances, corroborate only for patient group. Further, symptom subjective These findings highlight importance assessment population line our polysomnography work reveals isolated deficit NREM context similar architecture psychosis. Support (if any) K01 MH114012 (Baran)